Researchers from North Carolina State University and the National Institutes of Health (NIH) have prepared a method that can help to reduce the effects of histamine. It is been known that allergic reactions are driven by mast cells and basophils. The mast cell is the inflammatory cell found in tissues and the bloodstream, respectively, which function as part of our immune system.
The scientists explained when someone gets influence from an allergen such as immunoglobulin E (IgE), the allergen works through its receptor on the mast cell and basophils. During the process the mast cell and basophile get stimulated to pour out mediators such as histamine that trigger an allergic response.
To reduce the effects of histamine, most of the experts focus on other mediators or on dampening the body's overall immune response by the use of steroids. The viewpoint is neither totally effectual, and in the case of dampening the immune response, can have major drawbacks, stated the experts.