HIV Vaccine Strategy Works in Non-Human Primates

Johnson & Johnson along with other several other researchers after a deep study published results from a preclinical study conducted in non-human primates on a HIV vaccine regimen used. The study that was finally surfaced revealed that a vaccine regimen known as “heterologous prime-boost” which boost up the immune system, basically primes the immune system to increase the response, it proves to be a primary strategy for protection of human body against human immunodeficiency virus (HIV-1) infection and its associates.

The study reveals that despite gradual progress in HIV treatments, HIV ceases to be one of the greatest global health threats once as every year millions of people around the globe gets infected each year. Various vaccines were prepared that prevents HIV and works as a precaution. Johnson and Johnson recently collaborated with multiple stakeholders to form a unique vaccine to prevent this dangerous life taking illness, with the hope of eradicating it worldwide.  The study actually revealed that the basic investigational prime-boost vaccine provides overall protection with simian immunodeficiency virus (SIV) from becoming infected a virus similar to HIV that infects NHPs. It can also be demonstrated as that there is a strong bond between the ability of the vaccine regimen to be protective and to fight the virus referred as the number of antibody functions, herein called as polyfunctionality, so as it imparts for human use to supports the continued development of the vaccine regimen. These results have also been previously presented at various international conferences. The passive administration of HIV neutralizing of antibodies can protect macaques from finding it difficult to neutralize the chimeric simian-human immunodeficiency virus (SHIV) infection. The conditions for nAb-mediated protection after vaccination have not been established. The objective of this scheme is to identify the unidentified, vulnerable areas on HIV and teach them to track the immune system so as to make antibodies to protect them. In another Studies led by scientists of Scripps Research have shown that in case to bind the virus's outer part protein trimer the body needs to produce neutralizing the antibodies. To promote this thought, scientists had found that they can only protect animals from HIV through injecting them with neutralizing antibodies which are produced in the lab. But the main challenge was to get animals so as to make the neutralizing antibodies by themselves.

By: Anuja Arora

Content: https://www.sciencedaily.com/releases/2018/12/181214121811.htm