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The Protein Super-molecule to help Insulin Balancing

Insulin is a very important part of our physical system. The latest study done on an animal has reflected how the movement and storage of fat molecules in the liver is controlled by Insulin. It also shows how a barrier in this system could lead to non-alcoholic fatty liver disease that converts into circulating lipid levels associated with cardiovascular disease ultimately.

After a meal, the liver is told by the insulin to package and secrete excess nutrients into triglyceride-rich lipid particles into the blood so that it can be used by the rest of the body and ensure smooth functioning. After eating, the level of glucose rises, which induces the release of insulin to control blood sugar levels by increasing glucose uptake and reducing glucose production by the liver itself. It also controls blood lipid levels. The research has demonstrated that mTOR complex 1 (mTORC1), that is a protein super-molecule made up of several smaller proteins, is important for very low density lipoprotein (VLDL)-triglyceride production.

In the disorders that resist the production of insulin such as diabetes and obesity, hyperactive mTORC1 in liver leads to excess fat production and its transportation. The research also concludes that if mTORC1 is affected in a balanced way, then maybe it could help us prevent non-alcoholic fatty liver and heart disease that are very dangerous. If we understand the insulin signalling molecules then we can protect ourselves by these lifestyle diseases.

By: Anita Aishvarya


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