Causes Of Alzheimer's Disease

Alzheimer's disease, the most common cause of dementia among the aging, is symbolized by medal and skein in the brain, with most efforts at finding a cure focused on these abnormal structures. But a University of California, Riverside, research team has discovered proxy chemistry that could account for the various pathologies associated with the disease.
Plaques and tangles have so far been the focus of attention in this progressive disease that currently afflicts more than 5.5 million people in the United States. Plaques, deposits of a protein fragment called beta-amyloid, it is look like bundle in the spaces between neurons. Tangles, twisted fibers of tau, another protein, look like bundles of fibers that build up inside cells.
Ryan R. Julian, a professor of chemistry who led the research team said that - "The dominant theory based on beta-amyloid buildup has been in existence for decades, and dozens of clinical trials based on that theory have been solicit, but all have failed," "In addition to plaques, lysosomal storage is observed in brains of people who have Alzheimer's disease.
Study results are shown in ACS Central Science, a journal of the American Chemical Society.
An organelle within the cell, the lysosome serves as the cell's trashcan. Old proteins and lipids get sent to the lysosome to be broken down to their building blocks, which are then shipped back out to the cell to be built into new proteins and lipids. To maintain functionality, the synthesis of proteins is balanced by the degradation of proteins.
The lysosome, however, has a weakness: If what enters does not get broken down into little pieces, then those pieces also cannot leave the lysosome. The cell decides the lysosome is not working and "stores" it, meaning the cell pushes the lysosome to the side and proceeds to make a new one. If the new lysosome also fails, the process is repeated, resulting in lysosome storage.
By Byron D. Ford, a professor of biomedical sciences in the School of Medicine. This research was done in the lab on living cells. The researches could have ramification for other age-related diseases such as macular degeneration and cardiac diseases linked to lysosomal pathology.

By – Tripti Varun
Content - https://www.sciencedaily.com/releases/2019/08/190812144930.htm