Protein Has Appeared That Plays a Vital Role in Obesity and Metabolism Diseases

The recent studies of discovery of protein are normally found in abundance in fat; without it, our human body struggles for managing glucose and insulin.
With some unexpected findings related to a protein which is highly expressed in a fat tissue, scientists at the Scripps Research have also found out and reached to critical new understandings related to obesity and metabolism. Their discovery, which has reflected and appeared on Nov. 20 in the journal of Nature, could also result and lead for some fresh approaches for addressing problems like obesity and potentially an array of other diseases too.
The signalling protein which is known as PGRMC2, had not yet been extensively studied in our past. Short for the "progesterone receptor membrane component 2," it had also been detected in the uterus along with liver and several areas of our body. But unfortunately the lab of Enrique Saez, PhD, has seen that it was the most abundant in fat tissues – particularly for brown fat, which has the ability to turn food into the heat for maintaining body temperature -- and also become interested in its function there.
A Pivotal role: heme's travel guide
The team has also built on their recent discovery that PGRMC2 can bind to and can release an essential molecule called heme.
Saez who is Associate professor in the Department of Molecular Medicine has said that Heme's significance for many cellular processes has been there for a long time and is also known but we also have known that heme is toxic for cellular materials around it and would also need some sort of shuttling pathway.

By: Prerana Sharma
Content: https://www.sciencedaily.com/releases/2019/11/191120175618.htm